Histological changes in the process of fracture healing is a complex and involve a number of different cell activities. Fracture occurs, the presence of the different stages of osteoblast and osteoclast number and their synthetic cell interstitial far can not meet the demand of the fracture healing. Local cell regulation mechanisms (including precursor cells, mesenchymal cells, other synergy cells, capillaries, lymphatic, nerve growth factor autocrine and paracrine) to produce a sufficient number of osteoblasts and osteoclasts.

With the development of recombinant DNA technology, making it possible therapeutic areas. Such as growth factors and some other regulatory peptides for the regulation of cell metabolism, division and differentiation in the bone healing process. Part in the process of fracture healing growth factors and cytokines involved in the formation of bone cartilage has been reported in the literature.

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