Angiogenesis is an important part of the fracture healing process, a good blood supply to the fracture site of great significance in fracture repair. Vascular endothelial growth factor (vascular endothelial growth factor, VEGF) is a multifunctional cytokine, one of the most directly promotion of angiogenesis research has shown to play an important role of VEGF in bone formation and bone metabolism, the role is mainly by promoting angiogenesis involved in bone development in the form. Many recent studies have shown that VEGF is mainly derived from vascular endothelial cells is an important mediator of angiogenesis induced by multiple cytokines. On the other hand, increased expression levels of these cytokines will lead to increased expression of VEGF or synthetic. Various cytokines to promote bone efficacy and VEGF expression in varied ways, better application of what kind of cytokines, or combined with the feasibility of a variety of cytokines, there is no clear conclusion.

VEGF is a multifunctional cytokine secreted by platelets, megakaryocytes, endothelial cells and osteoblasts, and its role throughout human reproduction, development, tissue regeneration, repair, and tumor pathophysiological process. Many recent studies have shown that also play an important role of VEGF in bone formation and repair, the expression level directly affect the future into the bone's blood supply, affect the speed and quality of the osteoblast.

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