Post-traumatic bone tissue regeneration and repair is very complete, and its repair is often no scar residue. The reason why there is such a perfect bone tissue healing ability, because the memory of bone tissue factor in successful bone, bone growth factors. Bone morphogenetic proteins (bone morphogenetic pro-tein, BMP) because of its emphasis on direct induction of soft tissue into bone. Application BMP4cDNA probe to detect the fracture healing process foreign callus localization and distribution of BMP4 gene expression to explore the BMP4 gene expression outside in closed fracture healing callus formation. 64 healthy SD rats with closed tibial fractures animal models. 12 hours after fracture, 1,3,5,7,9,14 and 28 days after operation. Drawn underwent cryostat, the digoxigenin labeled BMP4cDNA probe situ hybridization. Rat fracture after 12 hours to three days, the detection of fractures around hematoma within cells and muscle emerging mesenchymal cells BMP4mRNA expression as a positive signal. Show that The trauma activates expression of BMP4mRNA, and was regional involved in the repair of fractures, the fracture hematoma and soft tissue has a very important role in the process of fracture healing.

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Follow-up period of 3 months to 6 years, with an average of 44 months follow-up of more than 3 years 28 patients (36 hips), 18 patients (22 hips) F ic cases at stage I, II, hip no significant pain and dysfunction, more than 3 years follow-up of 28 patients (36 hips) the hip Ha rris score, the mean preoperative (4 ± 9) minutes, mean postoperative (7 ± 7. 2) points (P <0. 0 1). The authors believe that the method of using bone morphogenetic protein can induce to enhance the osteogenic potential of bone marrow and allogeneic bone allograft fibula to provide direct mechanical support for block development and collapse of the femoral head lesions, bone allograft bone morphogenetic protein and autologous bone marrow can be used as the treatment of femoral F ic at Ⅰ, Ⅱ of avascular necrosis of a choice.

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Angiogenesis is an important part of the fracture healing process, a good blood supply to the fracture site of great significance in fracture repair. Vascular endothelial growth factor (vascular endothelial growth factor, VEGF) is a multifunctional cytokine, one of the most directly promotion of angiogenesis research has shown to play an important role of VEGF in bone formation and bone metabolism, the role is mainly by promoting angiogenesis involved in bone development in the form. Many recent studies have shown that VEGF is mainly derived from vascular endothelial cells is an important mediator of angiogenesis induced by multiple cytokines. On the other hand, increased expression levels of these cytokines will lead to increased expression of VEGF or synthetic. Various cytokines to promote bone efficacy and VEGF expression in varied ways, better application of what kind of cytokines, or combined with the feasibility of a variety of cytokines, there is no clear conclusion.

VEGF is a multifunctional cytokine secreted by platelets, megakaryocytes, endothelial cells and osteoblasts, and its role throughout human reproduction, development, tissue regeneration, repair, and tumor pathophysiological process. Many recent studies have shown that also play an important role of VEGF in bone formation and repair, the expression level directly affect the future into the bone's blood supply, affect the speed and quality of the osteoblast.

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