July 29, 2012

BMP, bFGF are two very important cytokines in bone formation

BMP, bFGF, has long been studies have shown that bone formation in two very important cytokines. BMP has long been proved to have a strong osteoinductive capacity. From bone cells themselves synthesized bFGF in an autocrine or paracrine in the bone matrix, combining bFGF and osteoblast-like cell surface receptor can promote its conversion to osteogenic cells. In vitro experiments confirmed that of bFGF can directly stimulate rat calvaria bone cells increased DNA synthesis, thereby increasing the number of osteoblasts the synthesis of collagen. Recently, studies have found that BMP, bFGF, and VEGF secretion and expression of the existence of a very close relationship. This experiment on the basis of the results of previous studies, observation of VEGF, respectively, in the application of rhBMP-2 expression and distribution of bFGF stimulation of bone marrow stromal cells, and the corresponding performance for osteogenesis do a comparison and found that in vitro application of rhBMP-2 and bFGF can indeed promote the expression of important mediators of VEGF to promote vascular endothelial cell proliferation, while increasing osteoblast performance. The joint application of these two cytokines can not only accelerate the bone marrow stromal cell proliferation and promote cell conversion to osteoblasts direction, so as to achieve better osteogenesis. First of bFGF to promote the proliferation of bone marrow stromal cells and then apply to promote the expression of osteogenic phenotype rhBMP-2, then the effect on the proliferation of bFGF and rhBMP-2 to promote differentiation are unaffected, which can play two cytokines in maximum biological effectiveness.

Posted by: BMP4protein at 01:43 PM | No Comments | Add Comment
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