July 29, 2012
VEGF is a multifunctional cytokine secreted by platelets, megakaryocytes, endothelial cells and osteoblasts, and its role throughout human reproduction, development, tissue regeneration, repair, and tumor pathophysiological process. Many recent studies have shown that also play an important role of VEGF in bone formation and repair, the expression level directly affect the future into the bone's blood supply, affect the speed and quality of the osteoblast.
VEGF was the introduction of bone tissue engineering technology is bound to promote new bone formation, increase the speed and quality of new bone. Exogenous VEGF in vivo half-life is short, and expensive, its application bring great inconvenience. Bone marrow stromal cells is a commonly used seed cells for bone tissue engineering, it contains many cells such as endothelial cells into fiber cells, macrophages, etc. can be secreted expression of VEGF in. How to stimulate the bone marrow stromal cells to promote the secretion of VEGF is another important means of expression of VEGF
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